The Gluten-Eating Enzyme That Makes Gluten Reduced Beers

Brewers Clarex™: The Gluten Enzyme

What is it?

Brewers Clarex™ is an enzyme which contains a proline-specific endo-protease that prevents the formation of chill haze in beer by hydrolyzing the haze-active proteins in the beverage. It’s also the enzyme used to produce most of the gluten reduced beers you see on the market today.

The Science Behind It

gluten reduced beers vs. gluten free beers“Brewer’s Clarex is an enzyme that degrades the epitopes on the antigen which causes the immune response known as Celiac disease. By degrading the responsible epitopes, the antigen is rendered harmless because there is no longer anything to interact with the human immune system. The epitopes are the section of the antigen that interact with the antibodies in people’s immune systems. To put it another way, consider a sea urchin. Now think of the sea urchin as an antigen and the spikes of the urchin to be the epitope. The prolyl endoprotease (Brewer’s Clarex) melts the spikes off of the urchin turning it into a simple, harmless tasty delicacy. Now the body is able to digest the antigen without harm.”




In a Nutshell

Brewers Clarex™ is an enzyme that was originally developed to prevent haze in beer, but researchers have since found that it possesses a secret power. The power to neutralize gluten in beer, rendering it safe to drink for many gluten sensitive individuals.

Are gluten reduced beers safe for Celiacs?

The short answer is, no. Ideally, those who battle Celiac Disease should have zero gluten in their diet. The safest choice for a Celiac is to drink a gluten free beer, a beer that was brewed with entirely gluten free ingredients to begin with, resulting in no need for an enzyme such as Brewers Clarex™. That being said, many people who should avoid gluten entirely, cheat sometimes. It’s a fact. In this case, a gluten reduced beer is your next best alternative.

gluten reduced beers vs. gluten free beers

Gluten Free vs. Gluten Reduced

Truly gluten free beers are brewed with 100% gluten free ingredients, often substituting wheat and barley with grains such as buckwheat or rice. These beers are the safest choice for the most sensitive of Celiacs.

Gluten reduced beers are required to keep their gluten content below 20ppm (parts per million), which is the nationally accepted threshold in North America deemed safe for consumption. This means that all gluten reduced beers have some trace of gluten and therefore possess the ability to trigger an immune response in a gluten intolerant individual.

Personally, as someone who battles Celiac Disease, I am able to drink a small amount of gluten reduced beer. When I limit myself to just one, my body seems to do alright. I don’t drink gluten reduced beer anymore. Here’s Why.


Breweries That Brew Gluten Reduced Beer With This Enzyme

Also known as “crafted to remove gluten” beers.


In the USA:


Brewery Rickoli (Colorado, USA)
Duck Foot Brewing (California, USA)
Living the Dream Brewing Company (Colorado, USA)
New Planet (Colorado, USA)  *GF and Gluten Reduced*
Odd 13 Brewing (Colorado, USA)
Omission (Oregon, USA)
Short’s Brewing Company (Michigan, USA)
Stone Brewing Co. (California, USA) 
Two Brothers Brewing Co. (Illinois, USA)
Uinta Brewing (Utah, USA)



In Europe:

Allendale Brewery
Bellfield Brewery
Black Isle Brewery
Brass Castle Brewery
Brew Dog
Cheddar Ales
Damm S.A
Drygate Brewing Co.
First Chop Brewing
Glebe Farm
Greene King Brewery
Hadrian Border Brewery Co.
Hambleton Ales
Hepworth Brewery
Kennet & Avon Brewery
Monty’s Brewing
Nene Valley Brewery
Piddle Brewing
Redwell Brewing
Sadler’s Ales
Stringers Beer
Westerham Brewing Co.
Wold Top Brewery
Wychwood Brewery



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Gluten free since 2011. An unapologetically passionate dancer of many paths. Lover of thunderstorms, golden retrievers, and AMAZING craft beer. Bitter and hoppy is my jam. ★

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4 years ago

Short’s Brewing in MI also makes a decent gluten-reduced beer, Space Rock.

4 years ago

New Planet Brewery makes a delicious gluten-reduced IPA called SECLUSION that is balanced and hoppy!
They also have a sessionable golden ale called TREAD LIGHTLY that is also gluten-reduced and appeals to the pilsner/lager crowd!

Silvana Castillo
Silvana Castillo
3 years ago

Thank you, would like to receive your free recipe for a gluten free beer. Also, would like to purchase your Clarex Enzyme for making a reduce gluten beer (do you add the enzyme at the beginning of the process? or at the end once fermentation has stopped?)

Thanks again,

Matt Phillips
Matt Phillips
9 months ago

So, I understand that the haze reducing enzyme reduces gluten. If more of the enzyme is added, does it further reduce gluten?

I have tried the gluten free kits – yuck! I have been an all-grain home brewer for over 20 years, but my son cannot tolerate gluten (Not a celiac). Bridger Brewing (great place!!!) in Bozeman, MT has nothing but gluten ‘free’ beers. They were excellent and worked well for my son.

9 months ago

Couple gluten-reduced (Brewer’s Clarex) offerings from Australia, with their statements of gluten reduceedness
• Bent Spoke (Canberra)
• Black Hops (Gold Coast)
• Wayward Brewing Company (Sydney)

I’m gluten intolerant (not celiac) and can comfortably have a session on any of the offerings from these 3 without ill effect.

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